By R.H.F Manske, H.L. Holmes
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This quantity is the outgrowth of a workshop held in October, 2000 on the Institute for Theoretical Atomic and Molecular Physics on the Harvard- Smithsonian middle for Astrophysics in Cambridge, MA. the purpose of this booklet (similar in subject matter to the workshop) is to offer an summary of recent instructions in antimatter physics and chemistry study.
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Extra resources for Alkaloids: Chemistry and Pharmacology, Volume 12
This same hydroxyl is also impervious t o mesylation, even though the tertiary C-13 hydroxyl undergoes this reaction smoothly (90).
This was confirmed by alkaline hydrolysis of X X I I t o the corresponding acid, which spontaneously cyclized to the lactone XXIII. Yamada ( 1 4 ) has studied the oxidation of hydroxylycoctonam (XX) with chromic acid and found that it is similar to the lead tetraacetate oxidation of hydroxylycoctonam ( 5 )and isolycoctonam (13)in that the a-ketol bond is cleaved, followed by elimination of a molecule of methanol. Two acid products (XXIVa and XXIVb) and a neutral one (XXV)were isolated from this reaction.
The later microanalysis data suggested that the oxidation proceeded without loss of a carbon atom, thus yielding an N-acetyl compound. However, oxonitine has also been reported as an oxidation product of mesaconitine (79, 80) 42 S. W. PELLETIER AND L. H. KEITH which possesses an N-methyl instead of an N-ethyl. Vigorous treatment of aconitine (partial structure CXXIV) with nitrous acid (81a)resulted in the cleavage of the N-ethyl and formation of the nitroso derivative CXXV. Acetylation of cxxv CXXIV * CHaCHz-N 5 OAc 5 OAc H CXXXI CXXXII CXXV with acetyl chloride gave a mixture of CXXVI and its acetolysis product CXXVII in 14% and 57% yields, respectively.